Tramadol- A Potent Analgesic

Tramadol- A Potent Analgesic

Tramadol is a painkiller which has a centrally acting analgesic structure related to that of morphine and codeine. It is a better option for the treatment of pain than the other two. The analgesic activity of Tramadol is contributed in two different mechanisms; Tramadol and metabolites are agonists of mu opiate receptors. It inhibits serotonin and norepinephrine reuptake. This increases the inhibitory effects on the transmission of pain in the spinal cord.

The drug is available in the forms of capsules for oral use, solution for intramuscular, subcutaneous, and intravenous injections, and as suppositories for rectal use. The solution and suppositories should only be used by the doctors. The oral formulations of Tramadol should not be used unless prescribed by the physicians. It dissolves completely and rapidly after the oral administration. The oral formulation also comes in two forms, the immediate release and the extended release.

Tramadol’s analgesic potency is about 10% of that of drugs like morphine. It provides immense relief in postoperative pain. It is beneficial for people who have a weak cardiopulmonary function; have undergone a surgery of the upper abdomen or thorax. It can also be used to reduce the pain caused by trauma, and biliary colic. It can manage chronic pain which has a nonmalignant or malignant origin, especially neuropathic pain.

Tramadol promises a normal life to everyone who has gone through a lot of physical pain. It is a synthetic drug. It doesn’t come from nature like codeine or morphine which is the derivate of Opium Poppy. Tramadol is completely synthetic. It is fully man-made; unlike hydrocodone which is semi-synthetic (has natural qualities but is made in the lab).

Tramadol has a dual-acting process. It has two neurotransmitters known as serotonin and norepinephrine, which regulate sleep and mood, and enhance concentration, respectively. This is a non-labeled use of Tramadol. the tramadol 50 mg dose is the most appropriate dose but it can be increased in the case of severity. 

 

 

 

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